منابع مشابه
Chemical Biology and Proteomics for Hunting Drug Targets for Human Malaria: An Update
Malaria is among the deadliest and wide-spread infectious diseases. Although, there has been significant progress in malaria prevention and control through chemotherapeutic approaches and vector control initiatives, half of the world’s population still inhabits in malaria endemic regions [1]. The situation is even more alarming due to the emergence of rapid parasitic resistance against commonly...
متن کاملDiversity cascades and malaria vectors.
The interactions between predator diversity and primary consumer abundance can include direct effects and indirect, cascading effects. Understanding these effects on immature Anopheles mosquitoes is important in sub-Saharan Africa, where most cases of malaria occur. Aquatic predators and immature mosquitoes were collected from shallow pools of varying age previously excavated by brickmakers in ...
متن کاملNew Targets for Drug Discovery against Malaria
A mathematical model which predicts the intraerythrocytic stages of Plasmodium falciparum infection was developed using data from malaria-infected mice. Variables selected accounted for levels of healthy red blood cells, merozoite (Plasmodium asexual phase) infected red blood cells, gametocyte (Plasmodium sexual phase) infected red blood cells and a phenomenological variable which accounts for ...
متن کاملRecent developments in chemical diversity
Diversity-oriented synthesis (DOS) is an important field involving the synthesis of libraries of diverse small molecules for applications including biological screening. The last decade has witnessed major progress in the field, with continued emphasis on structural and functional diversity for DOS library construction. A number of recent reviews have updated the community on this topic, includ...
متن کاملThe Host Genetic Diversity in Malaria Infection
Populations exposed to Plasmodium infection develop genetic mechanisms of protection against severe disease. The clinical manifestation of malaria results primarily from the lysis of infected erythrocytes and subsequent immune and inflammatory responses. Herein, we review the genetic alterations associated with erythrocytes or mediators of the immune system, which might influence malaria outcom...
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ژورنال
عنوان ژورنال: Nature
سال: 2016
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature19481